PHARMACEUTICAL & BIOTECHNOLOGY

In Pharmaceutical and Biotechnology Discovery, InforSense continues to develop and deliver domain specific applications and solutions that enable new ways of scientific research and improve the ROI of informatics projects..

For example, InforSense’s new Statistical Genetics based solution enables researchers to analyze the latest generation of genotyping arrays to find genetic variations that are most associated with disease. This is combined with tools to understand and characterize the variations using both bioinformatics and literature-informatics. All of the different components are delivered in an interactive web application to be used directly by research scientists.

Areas of Expertise

InforSense is successfully working with many life science companies to lower the cost and time required for a variety of high volume data analyses in the following areas:

• Sequence Analysis: Assembly, Analysis and Annotations of collections of Protein and DNA sequences. InforSense-based applications for sequence comparison have been delivered to scientists across biotechnology companies removing the need for hard-coded scripts and CGI’s
• Genomics: Sequence bioinformatics and the analysis of DNA Microarray experiments. InforSense based applications enable the standardization of QC methodologies across different research areas. The results of the standardized results allow different groups around companies to produce results that were comparable across different projects. 
• Metabonomics: Analysis and detection of bio markers from NMR Arrays. InforSense-based analytics solutions have been used by Life Science research groups to understand metabolic biomarkers for specific diseases. InforSense cross-domain analytics enables these to be associated with genomic bio-markers.
• High-Throughput Screening: Data Acquisitions, QC, Hit selection from HTS experiments InforSense solutions automate many activities of HTS enabling the rapid changing and customisation of processes for acquiring raw data, performing QC and analyzing experimental results as the laboratory protocol changes.
• Library Design: Design of libraries for screening applications: Advanced library design using High-Throughput enumeration and optimisation by generic algorithms have been deployed to make applications, that were considered high-end and specialist, accessible to all research scientists.
• QSAR / QSPR and ADME-Tox: Construction of models for QSAR/QSPR and ADME-Tox applications, scoring of molecules based models InforSense applications enable users to build models directly within chemical registration systems. Scoring of models can occur as part of the query process providing faster methods to score large quantities of molecules.
• Translational Medicine: Applications of clinical data to drug discovery research. InforSense has provided the first production translational medicine system where clinical research and discovery research are integrated to better design and execute research projects.

Areas of expertise beyond research:

• Pharmacovigilance: Detection of Drug Adverse events across patient populations.
• Sales and Marketing Automation: InforSense technology supports the Pharmaceutical and Biotechnology industries by delivering analytical applications across the complete life sciences research, development and commercial sides of the business.